Research development of Aurora-A kinase
10.3969/j.issn.1000-8179.20130946
- VernacularTitle:Aurora-A 激酶的研究进展
- Author:
Xiangqian ZHENG
;
Ming GAO
;
Xiubao REN
;
Jin Q.CHENG
- Publication Type:Journal Article
- Keywords:
Aurora-A kinase;
molecular inhibitor;
target therapy
- From:
Chinese Journal of Clinical Oncology
2014;46(4):272-275
- CountryChina
- Language:Chinese
-
Abstract:
Aurora-A is a mitotic serine/threonine kinase that is evolutionally conserved and localized at the centrosome. Aurora-A activation is required for mitotic entry, centrosome maturation, and centrosome separation. Aurora-A is frequently amplified and/or over-expressed in breast, ovarian, esophageal, colon, lung, and bladder cancers. Aurora-A has recently become a new target of malignant tumors. The Aurora-A inhibitor can be combined with other chemotherapeutic drugs to provide a new way for cancer treatment. In this study, we review the function and inhibitor of Aurora-A kinase.
