Correlation of lymphatic vessel density with a high mobility group Box-1 protein and tumor-associated macrophages in cervical carci-noma
10.3969/j.issn.1000-8179.20131738
- VernacularTitle:高迁移率族蛋白1和肿瘤相关巨噬细胞与宫颈癌淋巴管密度的相关性研究
- Author:
Yan LI
;
Quan HAO
- Publication Type:Journal Article
- Keywords:
cervical squamous cell carcinoma;
high mobility group box-1 protein;
tumor-associated macrophage;
lymphatic vessel density;
prognosis
- From:
Chinese Journal of Clinical Oncology
2014;46(4):222-226
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To detect the correlation of lymphatic vessel density (LVD) with a high mobility group box-1 Protein (HMGB1) and tumor-associated macrophages (TAMs) in cervical carcinoma and the effect on prognosis. Methods:Immunohistochem-istry was applied to detect HMGB1, CD68, and D2-40 expressions in cervical squamous cell carcinoma in 93 cases. t test,χ2 test, Spear-man rank correlation analysis, Kaplan-Meier method, and Cox regression were performed to analyze the expression levels, correlation, and prognosis. Results: HMGB1 protein, CD68, and D2-40 were highly expressed in CSCC. As HMGB1 and TAM expressions in-creased, lymphatic vessel density increased. As HMGB1 and TAM expressions decreased, lymphatic vessel density decreased. Positive correlations were also found between the HMGB1 protein, TAM content, and LVD. In the group with low HMGB1 and TAM expres-sions, the survival time of the group with a high LVD expression was significantly lower than that of the group with a low LVD expres-sion. A multivariate Cox regression model showed that HMGB1 and lymph node metastasis were independent prognostic factors. TAMs and LVD were not independent prognostic factors. Conclusion:HMGB1 proteins and TAMs were highly expressed in CSCC. Patients who exhibit increased HMGB1 expression or increased TAM count consequently show enhanced LVD expressions, increased lymph node metastasis, and poor prognosis.
