CBLB502 Protects mice radiation pneumonitis and pulmonary fibrosis

VernacularTitle:CBLB502对放射性肺炎和肺纤维化的防护作用研究
Author: Yulei QIAO ; Zhidong WANG ; Jinfeng XIA ; Xifeng TIAN ; Xueqing ZHANG ; Shixiang ZHOU ; Haixiang LIU ; Ying CHEN
Publication Type:Journal Article
Keywords: TLR5; CBLB502; radiation pneumonitis; pulmonary fibrosis; thoracic radiotherapy
From: Military Medical Sciences 2014;(1):26-30
CountryChina
Language:Chinese
Abstract: Objective To investigate the protective effect of CBLB 502 on radiation pneumonitis and pulmonary fibrosis for confirming the feasibility of CBLB502 as a clinical anti-radiation drug release.Methods With a single 20 Gy irradia-tion, C57BL/6J mice was sacrificed on 24 h, 1 month, 3 months and 5 months and lung tissue was assayed by TUNEL method for apoptosis of alveolar epithelial cells and endothelial cells , HE staining showing fibrosis changes , immunohisto-chemistry detecting the expression of specific indicators , as well as pathological changes of the fur and skin radiated site . Results CBLB502 inhibits apoptosis in mice alveolar epithelial cells and vascular endothelial cells after irradiation , slowing the process of pulmonary fibrosis , while reducing the expression of laminin and maintaining the expression of surfac-tant protein B, and the skin inflammation also significantly reduced .Conclusion CBLB502 could alleviate the occurrence of radiation pneumonitis and pulmonary fibrosis as well as radiation-induced skin injury .