CBLB502 Protects mice radiation pneumonitis and pulmonary fibrosis
10.7644/j.issn.1674-9960.2014.01.008
- VernacularTitle:CBLB502对放射性肺炎和肺纤维化的防护作用研究
- Author:
Yulei QIAO
;
Zhidong WANG
;
Jinfeng XIA
;
Xifeng TIAN
;
Xueqing ZHANG
;
Shixiang ZHOU
;
Haixiang LIU
;
Ying CHEN
- Publication Type:Journal Article
- Keywords:
TLR5;
CBLB502;
radiation pneumonitis;
pulmonary fibrosis;
thoracic radiotherapy
- From:Military Medical Sciences
2014;(1):26-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of CBLB 502 on radiation pneumonitis and pulmonary fibrosis for confirming the feasibility of CBLB502 as a clinical anti-radiation drug release.Methods With a single 20 Gy irradia-tion, C57BL/6J mice was sacrificed on 24 h, 1 month, 3 months and 5 months and lung tissue was assayed by TUNEL method for apoptosis of alveolar epithelial cells and endothelial cells , HE staining showing fibrosis changes , immunohisto-chemistry detecting the expression of specific indicators , as well as pathological changes of the fur and skin radiated site . Results CBLB502 inhibits apoptosis in mice alveolar epithelial cells and vascular endothelial cells after irradiation , slowing the process of pulmonary fibrosis , while reducing the expression of laminin and maintaining the expression of surfac-tant protein B, and the skin inflammation also significantly reduced .Conclusion CBLB502 could alleviate the occurrence of radiation pneumonitis and pulmonary fibrosis as well as radiation-induced skin injury .
