Neural stem cell transplantation:its actuality and future used for treatment of hypoxic-ischemic encephalopathy
10.3969/j.issn.2095-4344.2014.01.024
- VernacularTitle:应用于缺血缺氧性脑病治疗的神经干细胞移植：现实与未来
- Author:
Tan YANG
;
Hua LIU
;
Zhaoguang WANG
;
Jifan GAO
;
Dongjie XIAO
;
Yunshan WANG
- Publication Type:Journal Article
- Keywords:
stem cells;
neural stem cells;
hypoxia,brain;
stem celltransplantation
- From:
Chinese Journal of Tissue Engineering Research
2014;(1):143-148
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Many studies have showed that neural stem cells therapy is a new strategy for hypoxic-ischemic encephalopathy.
OBJECTIVE:To review and analyze the status of research, transplantation strategies and mechanism of neural stem cells therapy for treatment of hypoxic-ischemic encephalopathy.
METHODS:A computer-based retrieval was performed in PubMed and CNKI database to search papers published from August 2000 to August 2013 using the key words of“hypoxic-ischemic encephalopathy, neural stem cells”in English and Chinese. The papers with objective-independent and repetitive contents were excluded, and final y 39 papers were included for final analysis.
RESULTS AND CONCLUSION:Neural stem celltransplantation can promote recovery of neurological function, which brings new hope to hypoxic-ischemic encephalopathy patients. But the study is at a primary stage and limited in laboratory. There are many critical factors that hinder the clinical transplantation, such as delivery path, transplantation time, single or combined transplantation, mechanisms of action. Application of neural stem cells requires further investigation.
