Research progress and application prospect of induced pluripotent stem cells
10.3969/j.issn.2095-4344.2014.01.025
- VernacularTitle:诱导性多潜能干细胞的研究进展及应用前景
- Author:
Feifei LIU
;
Zongliu HOU
- Publication Type:Journal Article
- Keywords:
stem cells;
embryonic stem cells;
efficiency;
transcription factors
- From:
Chinese Journal of Tissue Engineering Research
2014;(1):149-154
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Induced pluripotent stem cells research has become a hot topic nowadays, because it can avoid the immune rejection and ethical issues in stem cellresearch and have characteristics is similar to the embryonic stem cells.
OBJECTIVE:To review prospect and progress of induced pluripotent stem cells, and to find out some problems about the induced pluripotent stem cells in inducing method, efficiency, safety and application which need to be solved.
METHODS:Kjmed database was searched by the first author using key words of“induced pluripotent stem cells, efficiency, disease model, clinical application”in English to retrieve relevant articles published from January 2003 to June 2013. Literatures addressing induced pluripotent stem cells were included, and the repetitive researches were excluded.
RESULTS AND CONCLUSION:A total of 112 documents were retieved, and final y 32 articles were retained after deleting unrelated and repetitive ones. Induced pluripotent stem cells have very high application value and prospects in the somatic celltransplantation, tissue engineering, drug screening and establishment in vitro of disease models. But this technology is stil in the stage of research and exploration, and there are many technical problems that need to be solved.
