The association between angiotensin converting enzyme gene polymorphism and Alzheimer’s disease in Jiamusi region
10.3969/j.issn.2095-4344.2014.02.016
- VernacularTitle:血管紧张素转换酶基因多态性与佳木斯地区阿尔茨海默病的关系
- Author:
Shuping ZHANG
;
Zhaobo XUAN
;
Zuoyi HUANG
;
Yingqin LIU
;
Qing LIU
;
Xiangyu WANG
;
Chengji WU
;
Limin YANG
;
Abbas ZEESHAN
- Publication Type:Journal Article
- Keywords:
peptidyl-dipeptidase A;
Alzheimer disease;
genotype;
gene frequency;
hypertension
- From:
Chinese Journal of Tissue Engineering Research
2014;(2):259-264
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Angiotensin-converting enzyme as a key enzyme of the renin-angiotensin system, through the degradation effects of substance P mechanism, is involved in the occurrence and development of Alzheimer’s disease.
OBJECTIVE:To research the relationship between angiotensin-converting enzyme gene polymorphism and Alzheimer’s disease in Jiamusi region, as wel as the effect of gender and hypertension on the relationship.
METHODS:This case-control study included 96 Alzheimer’s disease patients. Another 102 subjects served as controls coming from the same area and in the same environmental condition. DNA segments were amplified using PCR in 20 g/L agarose gel electrophoresis and observed under ultraviolet lamp. II, ID, DD genotypes and genotype frequencies were calculated for statistical analysis. On this basis, according to clinical data col ected, we investigated association of Alzheimer’s disease with hypertension and gender.
RESULTS AND CONCLUSION:There was significant difference between Alzheimer’s disease patients and controls in angiotensin-converting enzyme genotypes and al ele frequency. There was statistical y significant difference between Alzheimer’s patients with hypertension and controls in angiotensin-converting enzyme genotypes and al ele frequency. There was no statistical difference between Alzheimer’s disease patients with different genders and controls in angiotensin-converting enzyme genotypes and al ele frequency. These findings indicate that there are some relationships between angiotensin-converting enzyme polymorphism and Alzheimer’s disease. II genotype is a risk factor for Alzheimer’s disease, angiotensin-converting enzyme II genotype is a risk factor for Alzheimer’s disease with hypertension.
