Aberrant resting-state functional connectivity of default mode and salience network in patients with schizo-phrenia
10.3936/j.issn.1002-0152.2013.12.009
- VernacularTitle:精神分裂症默认网络与突显网络的静息态fMRI研究
- Author:
Yingchan WANG
;
Weijun TANG
;
Jianye ZHANG
;
Dengtang LIU
;
Kaida JIANG
;
Zeping XIAO
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Functional magnetic resonance imaging (fMRI);
Default mode network;
Salience net-work;
Independent component analysis (ICA)
- From:
Chinese Journal of Nervous and Mental Diseases
2013;(12):744-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feature of functional connectivity of default mode network (DMN) and salience network (SN) in unmedicated schizophrenia patients during a resting state by functional magnetic resonance imaging (fM-RI). Methods The SPM8 and DPARSFA softwares combined with independent component analysis (ICA) were used to in-vestigate functional connectivity (FC) of the DMN and SN in 27 unmedicated patients with schizophrenia and 27 age-and gender-matched healthy controls. Results Concerning the DMN, patients with schizophrenia showed decreased FC in right inferior frontal gyrus , right precuneus(unadjusted P<0.05)and increased FC in right middle cingulate gyrus, left middle frontal gyrus(unadjusted P<0.05). With regard to the SN, patients showed reduced connectivity in left inferior frontal gyrus, right inferior frontal gyrus, left anterior cingulate, left postcentral gyrus(unadjusted P<0.05)and increased connectivity in left superior temporal gyrus(unadjusted P<0.05). Correlation analyses showed that the increased FC of left superior temporal gyrus significantly correlated with PANSS-positive symptoms(r=0.568,P=0.002)and decreased FC of right precuneus significantly negatively correlated with delusion symptom(r=-0.458,P=0.016). Conclusion This study provides evidence for resting state functional abnormalities of DMN and SN in unmedicated schizophrenia patients. These aberrant function connectivities in some brain regions of the two networks could be a source of abnormal introspectively-oriented mental actives.
