Expression of S100A7 in basal-like breast carcinoma and its clinical significance
10.3760/cma.j.issn.1673-422X.2014.03.022
- VernacularTitle:S100A7在基底细胞样乳腺癌中的表达及临床意义
- Author:
Li JIANG
;
Wenming ZHAO
;
Jirui SUN
;
Bingjuan ZHOU
;
Jinku ZHANG
- Publication Type:Journal Article
- Keywords:
S100 proteins;
Carcinoma,basal cell;
Breast neoplasms;
Neovascularization,pathologic
- From:
Journal of International Oncology
2014;41(3):229-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the protein expressions of S100A7 and CD34 in basal-like breast carcinoma and analyze the clinical relationship between S100A7 and basal-like breast cancer and the connection with CD34 markers microvessel denisity (MVD).To study the function of S100A7 in basal-like breast cancer angiogenesis,invasion and metastasis.Methods Immunohistochemistry (IHC) was used to detect the expressions of S100A7 and CD34 in 60 cases of basal-like breast cancer,40 cases of non basal-like breast cancer and 20 cases of normal breast tissues.Results The expressions of S100A7 in basal-like breast cancer,non basallike breast cancer and normal breast tissues were 83.33％,62.50％ and 35.00％ respectively.There were significant differences among them (x2 =5.556,P ＜ 0.051; x2 =17.107,P ＜ 0.05; x2 =4.051,P ＜ 0.05).There was positive correlation between S100A7 and lymph node metastasis,TNM staging and MVD of basal-like breast cancer patients.But there was no significant correlation between S100A7 and patient's age and tumor sizes.Conclusion The up-regulation of S100A7 expressions may be associated with the occurrence and development,invasion and metastasis,angiogenesis of basal-like breast cancer.The effects of S100A7 promoting angiogenesis may be an important factor in the acceleration of the local invasion and distant metastasis in basallike breast cancer.
