Research progress of D4-GDI in the pathogenesis of lung cancer
10.3760/cma.j.issn.1673-422X.2014.03.014
- VernacularTitle:D4-鸟苷酸解离抑制因子在肺癌发病机制中的研究进展
- Author:
Xinyue LUO
;
Ruicheng HU
;
Aiguo DAI
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Inflammation;
Signaling pathway;
Lung neoplasms;
D4-GDI
- From:
Journal of International Oncology
2014;41(3):206-208
- CountryChina
- Language:Chinese
-
Abstract:
As one of the main members of the Rho GDI dissociation inhibitory factors,D4-GDI inhibits the dissociation of Rho protein and GDP,which is also involved in a wide range of celluar functions,such as cell contraction,adhesion,migration,proliferation and apoptosis.Recently,accumulating evidence has been suggested that D4-GDI is involved in the pathogenesis of several pulmonary diseases,such as lung cancer.Intervention of D4-GDI expression may improve the pathological changes and prognosis of these diseases.
