A double-negative feedback loop lin28-let-7 and tumor
10.3760/cma.j.issn.1673-422X.2014.03.002
- VernacularTitle:双向负反馈环路lin28-let-7与肿瘤
- Author:
Jingtao PENG
;
Ren MO
;
Jie FAN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
MicroRNAs;
RNA-binding proteins;
Neoplastic stem cells
- From:
Journal of International Oncology
2014;41(3):165-168
- CountryChina
- Language:Chinese
-
Abstract:
The microRNA let-7 family,functioning as a tumor suppressor,has emerged as a regulator of stem cell differentiation and tumor repression.The RNA-binding protein lin28 is a stem cell pluripotency factor,which contributes to the maintenance of stem cell characteristics and promoting cell malignant transformation.lin28 can block the maturity of let-7 by combining with the precursors of let-7 family miRNAs,which is itself able to repress lin28 by binding to the 3'-UTR of lin28 transcripts,thus forming a feedback loop.The double-negative feedback loop comprising lin28 and let-7 is involved in several biological processes such as differentiation of stem cell,tumorigenesis,invasion and metastasis,drug resistance and relapse,which couldbe a potential target for cancer therapy.
