Relationship between Wnt/β-catenin signaling pathway and pancreatic cancer
10.3760/cma.j.issn.1006-9801.2013.12.023
- VernacularTitle:Wnt/β-catenin信号通路与胰腺癌相关性的研究进展
- Author:
Yumeng CUI
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Wnt/β-catenin signaling pathway;
Cell cycle;
Apoptosis;
Tumor stem cells;
Angiogenesis
- From:
Cancer Research and Clinic
2013;25(12):856-858
- CountryChina
- Language:Chinese
-
Abstract:
Wnt signaling pathway is one of canonical pathways that can regulate diverse processes such as cell proliferation,differentiation,migration.Interaction between Wnt ligands and Wnt receptors results in an activation ofdifferent intracellular signaling pathways,and Wnt/β-catenin signaling pathway has been proved to have a close relationship with pancreatic cancer.This review presents a brief overview of Wnt/β-catenin signaling pathway in the mechanism of the tumorigenesis of the pancreatic cancer at deregulation of cell cycle,apoptosis,cancer stem cells and angiogenesis.
