Research progress of glioma stem cells and the related signal transduction pathways
10.3760/cma.j.issn.1006-9801.2013.12.022
- VernacularTitle:胶质瘤干细胞及其相关信号通路的研究进展
- Author:
Junqiang HUANG
;
Yu YANG
- Publication Type:Journal Article
- Keywords:
Glioma;
Stem cells;
Signal transduction
- From:
Cancer Research and Clinic
2013;25(12):853-855
- CountryChina
- Language:Chinese
-
Abstract:
Gliomas harbor a small population of cells termed glioma stem-like cells (GSC),which have the ability to undergo self-renewal and initiate tumorigenesis.GSCs are resistant to a wide variety of chemotherapeutic agents and possess a remarkable ability to recover from cytotoxic therapy.Furthermore,GSCs play a crucial role in RT failure,as tumors surviving RT are enriched in GSCs.Therefore,an alternative strategy involving selective targeting of this functionally distinct chemo-and radiation resistant small group of GSCs rather than the bulk of the tumor may be more successful in treating this deadly disease.GSC exhibit various alterations to signaling pathway activity,which are associated with self-renewal and neoplastic proliferation.These altered pathways may represent possible targets for GSC.
