Clinical observation of the patients with malignant coelom effusion treated with pseudomonas aeruginosa injection combined with ulinastatin by body cavity injection
10.3760/cma.j.issn.1006-9801.2014.01.005
- VernacularTitle:铜绿假单胞菌注射液联合乌司他丁治疗晚期恶性体腔积液的临床分析
- Author:
Guangzhi WAN
;
Jingzhi GUAN
;
Penghui LIU
;
Wenhua ZHU
;
Chao PAN
- Publication Type:Journal Article
- Keywords:
Pseudomonas aeruginosa injection;
Ulinastatin;
Malignant coelom effusion
- From:
Cancer Research and Clinic
2014;26(1):17-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect and safety of pseudomonas aeruginosa injection (PA-MSHA) combined with ulinastatin (UTI) injection in the treatment of patients with malignant pleural effusion and/or ascites.Methods 52 patients were randomly divided into PA-MSHA group and PA-MSHA combined with UTI group,each group including 26 patients.All patients were given ultrasonic testing before treatment.The single drug group was given PA-MSHA 10 ml intrapleural and/or intraperitoneal injection.The two-drug combination group was given PA-MSHA 10ml and UTI 300 000 U,twice per week.Evaluation of the efficacy and adverse reaction was performed after 4 times.Results The effective rate of single PA-MSHA group was 34.6 ％ (CR 1 case,PR 8 cases),while the effective rate of PA-MSHA combined with UTI group was 61.5 ％ (CR 2 cases,PR 14 cases).The effective rate of PA-MSHA combined with UTI group was statistically higher than that of single PA-MSHA group (P ＜ 0.05).8 cases got fever in single PA-MSHA group,3 cases in PA-MSHA combined with UTI group got fever,side effect had no statistical significance (P ＞ 0.05).Conclusion PA-MSHA combined with UTI has better effect in the treatment of patients with malignant pleural effusion and/or ascites compared with single PA-MSHA,and both treatments have low side effects.
