Dust mite allergy may be a risk factor for early-onset and severe type of alopecia areata
10.3760/cma.j.issn.0412-4030.2014.01.014
- VernacularTitle:尘螨过敏可能是斑秃患者早发和重型的危险因素之一
- Author:
Shuifeng LI
;
Xiaoting ZHANG
;
Shiling QI
;
Yanting YE
;
Hui CAO
;
Yuqing YANG
;
Xingqi ZHANG
- Publication Type:Journal Article
- Keywords:
Alopecia areata;
Anaphylaxis;
Pyroglyphidae;
Cockroaches
- From:
Chinese Journal of Dermatology
2014;47(1):48-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features of,concurrence of allergic diseases in,as well as serum levels of total immunoglobulin E (IgE) and specific IgEs in,232 patients with alopecia areata (AA),and to estimate their relationship.Methods Serum samples were obtained from 232 patients with AA and 110 healthy controls from a health check-up center.Turbidimetric immunoassay and fluorescence-based enzyme-linked immunosorbent assay were performed to measure total IgE and specific IgEs to common antigens in these serum samples,respectively.Statistical analysis was carried out by t test,rank sum test,and chi-square test.Results The patients showed a male/female ratio of 127 ∶ 105 with an average age of (26.4 ± 13.8) years and clinical course of (25.3 ± 42.3) months.Among these patients,89 (38.4%) suffered from severe AA,and 67 (28.9%) reported at least one allergic disease.No significant difference was found in the positive rates of serum total IgE (30.2% vs.21.8%,P > 0.05),anti-Dermatophagoides pteronyssinus and-Cockroach specific IgEs or the serum levels of antiDermatophagoides pteronyssinus or-Cockroach IgE between the patients and healthy controls.The three most common specific IgEs were anti-Dermatophagoides pteronyssinus IgE (34.1%),anti-Dermatophagoides farinae IgE (31.9%) and anti-Cockroach IgE (22.5%) in patients with AA,whose serum levels were positively correlated with the level of serum total IgE separately.A significant increase was observed in the positive rates and serum levels of anti-Dermatophagoides pteronyssinus and-Cockroach specific IgEs in patients with severe and diffuse AA compared with the healthy controls and patients with mild AA,as well as in those of anti-Dermatophagoides pteronyssinus specific IgE in child patients with AA compared with the healthy controls and adult patients with AA (P < 0.05 or 0.01).Conclusions Dust mite allergy may be not only a pathogenic factor for severe,diffuse and childhood AA,but also a risk factor for early onset and severe type of AA.