Role of histone acetylation in diabetes mellitus
10.3760/cma.j.issn.1000-6699.2014.02.023
- VernacularTitle:组蛋白乙酰化与糖尿病
- Author:
Yanfei WANG
;
Can HOU
;
Xin SU
;
Zhiguang ZHOU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Histone acetylation;
Metabolic memory;
Genome wide association studies
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(2):167-170
- CountryChina
- Language:Chinese
-
Abstract:
Histone acetylation is a crucial part of histone modifications in epigenetics.Histone acetylation is involved in the onset of diabetes and diabetic complications,through the mechanism of inducing hyperglycemia by means of metabolic memory effect,interfering islet development and regulating the expression of inflammatory factors and pathogenic genes.Genome-wide association studies are gradually unveilling the pathogenesis of diabetes and preclinical studies are rapidly elucidating that histone deacetylase should be considered as a new target for the treatment of diabetes.
