Effect of high fat diet on bone mass in young mice
10.3760/cma.j.issn.1000-6699.2014.02.017
- VernacularTitle:高脂饮食对幼年小鼠骨量影响的研究
- Author:
Lei SHU
;
Mingquan LI
;
Xiaoxia WANG
;
Xinyi WANG
;
Ming ZHAO
- Publication Type:Journal Article
- Keywords:
Osteoclasts;
Osteoblasts;
Bone resorption;
PPARγ
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(2):150-152
- CountryChina
- Language:Chinese
-
Abstract:
Eight-weeks old C57BL/6J male mice were treated with normal or high fat diet for4 weeks,and then bone mass,number and activity of osteoclasts,differentiation of osteoblasts from bone marrow mesenchymal cells and the change in lipid genes expression were studied.Compared with the normal diet treated group,bone mass of femur from high fat diet treated animal was decreased,but there were increased number and activity of osteoclasts and raised lipid genes expression levels.Besides,no obvious change was found in differentiation of osteoblasts from bone marrow mesenchymal cells.The loss of bone mass induced with high fat diet in young mice was mainly due to increased activity of osteoclasts and bone resorption.
