Role of cardiovascular protection played by dipeptidyl peptidase 4 inhibitors
10.3760/cma.j.issn.1000-6699.2014.01.021
- VernacularTitle:DPP-4抑制剂的心血管保护作用
- Author:
Wenying YANG
- Publication Type:Journal Article
- Keywords:
Dipeptidyl peptidase 4 inhibitor;
Diabetes;
Cardiovascular protection;
Tissue repair
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(1):79-82
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease is a common complication of type 2 diabetes,causing considerable fatality.Dipeptidyl peptidase 4 (DPP-4) inhibitors are new drugs for treatment of diabetes.Current studies have demonstrated that these drugs play an important role in cardiovascular protection.DPP-4 inhibitors can lower blood pressure,regulate blood lipid,and suppress inflammation and atherosclerosis.Treatment with DPP-4 inhibitors results in reduced size of myocardial infarct,reduced myocardial ischemia/reperfusion injury,increased myocardial cell regeneration,and improved heart function,etc.Recent studies have also found that DPP-4 inhibitors are able to mobilize progenitor cells to the sites of cardiovascular injury and thus to promote tissue repair.
