An association study of six-transmembrane protein of prostate 2 gene with metabolic index and tumour necrosis factor in Uygur population
10.3760/cma.j.issn.0578-1426.2014.02.013
- VernacularTitle:前列腺六次跨膜蛋白2基因变异与维吾尔族人群代谢指标及肿瘤坏死因子的关系
- Author:
Feiya ZU
;
Yunwei BI
;
Xiaoguang YAO
;
Hongmei WANG
;
Ling ZHOU
;
Nanfang LI
- Publication Type:Journal Article
- Keywords:
Polymorphism,genetic;
Uygur nationality;
STAMP2 gene;
Tumour necrosis factor α
- From:
Chinese Journal of Internal Medicine
2014;53(2):131-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between genetic polymorphisms of sixtransmembrane protein of prostate 2 (STAMP2) and metabolic index,TNFα in Xinjiang Uygur population.Methods STAMP2 gene functional regions were sequenced in Uygur Xinjiang population diagnosed as metabolic syndrome.Patients were divided into the following three groups by their TNFα concentration:the high level group(TNFα≥7.95 μg/L,n =313),the moderate level group(TNFα ＞5.34-＜7.95 μg/L,n =268)and the low level group(≤5.34 μg/L,n =313).The selected representative variations were genotyped by TaqMan-PCR in 894 Uygur individuals.The association of the genetic variations of STAMP2 gene with metabolic index and TNFα was analyzed.Results Three representative variations were genotyped,including rs8122,rs1981529 and rs34741656.The genotype distribution and allele frequencies of rs8122and rs1981529 were statistically different among the three groups (P ＜ 0.05),while no difference was observed with rs34741656(P ＞0.05).By ANOVA analysis,statistical difference was showed between the rs1981529 polymorphism AA and AG in the concentration of TNFα(P ＜ 0.05).None of the polymorphisms was significantly associated with TC,HDL-C,LDL-C and TG (P ＞ 0.05).Conclusion Two STAMP2 gene polymorphisms,rs8122 and rs1981529 are associated with the concentration of TNFα in Xinjiang Uygur population.
