Estimated glomerular filtration rate and associated risk factors in overweight or obese patients with type 2diabetes and normal urine microalbumin level
10.3760/cma.j.issn.1000-6699.2014.01.011
- VernacularTitle:尿微量白蛋白阴性的超重肥胖2型糖尿病患者估算的肾小球滤过率下降的相关危险因素分析
- Author:
Ruyi ZHANG
;
Jiao WANG
;
Rongping CHEN
;
Rui YANG
;
Jia SUN
;
Qingqing SONG
;
Dehong CAI
- Publication Type:Journal Article
- Keywords:
Overweight;
Obesity;
Diabetes mellitus,type 2;
Estimated glomerular filtration rate;
Urine microalbumin
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(1):43-46
- CountryChina
- Language:Chinese
-
Abstract:
From August 2011 to March 2012,5 241 type 2 diabetic patients with body mass index ≥ 24kg/m2 were enrolled from 60 hospitals in Guangdong Province.According to estimated glomerular filtration rate (eGFR),a total of 2 631 subjects with norml urine microalbumin level (＜30 ng/L) were divided into normal eGRF group and decreased eGRF group.Binary logistic regression was used to analyze the associations between eGFR and its related risk factors.The results showed that age,blood uric acid,blood urea nitrogen,history of hypertension and coronary heart disease,family history of diabetes,and hyperuricemia were positively related to lowering of eGFR (P＜ 0.05 or P＜0.01).HbA1C＜7％,regular glucose monitoring,and regular physical activity were negatively related to eGFR decrease (all P＜ 0.01).These results suggest that urine microalbumin and eGFR should be applied to overweight or obese patients with type 2 diabetes in order to screen diabetic nephropathy.Furthermore,intensive control of blood glucose,uric acid,and blood pressure is beneficial to lowering the risk of diabetic nephropathy.
