Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease: Methodology and Baseline Sample Characteristics.
- Author:
Min Soo BYUN
1
;
Dahyun YI
;
Jun Ho LEE
;
Young Min CHOE
;
Bo Kyung SOHN
;
Jun Young LEE
;
Hyo Jung CHOI
;
Hyewon BAEK
;
Yu Kyeong KIM
;
Yun Sang LEE
;
Chul Ho SOHN
;
Inhee MOOK-JUNG
;
Murim CHOI
;
Yu Jin LEE
;
Dong Woo LEE
;
Seung Ho RYU
;
Shin Gyeom KIM
;
Jee Wook KIM
;
Jong Inn WOO
;
Dong Young LEE
Author Information
- Publication Type:Original Article
- Keywords: Alzheimer's disease; Early diagnosis; Prediction; Biomarker; Prospective cohort study
- MeSH: Aging*; Alzheimer Disease*; Biomarkers; Brain*; Cohort Studies; Dementia; Early Diagnosis*; Genetic Markers; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Mild Cognitive Impairment; Neuroimaging; Pathology; Prospective Studies
- From:Psychiatry Investigation 2017;14(6):851-863
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's disease (KBASE) aimed to recruit 650 individuals, aged from 20 to 90 years, to search for new biomarkers of Alzheimer's disease (AD) and to investigate how multi-faceted lifetime experiences and bodily changes contribute to the brain changes or brain pathologies related to the AD process. METHODS: All participants received comprehensive clinical and neuropsychological evaluations, multi-modal brain imaging, including magnetic resonance imaging, magnetic resonance angiography, [11C]Pittsburgh compound B-positron emission tomography (PET), and [18F]fluorodeoxyglucose-PET, blood and genetic marker analyses at baseline, and a subset of participants underwent actigraph monitoring and completed a sleep diary. Participants are to be followed annually with clinical and neuropsychological assessments, and biannually with the full KBASE assessment, including neuroimaging and laboratory tests. RESULTS: As of March 2017, in total, 758 individuals had volunteered for this study. Among them, in total, 591 participants–291 cognitively normal (CN) old-aged individuals, 74 CN young- and middle-aged individuals, 139 individuals with mild cognitive impairment (MCI), and 87 individuals with AD dementia (ADD)–were enrolled at baseline, after excluding 162 individuals. A subset of participants (n=275) underwent actigraph monitoring. CONCLUSION: The KBASE cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (CN, MCI, and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.
