Association between CTLA-4 gene polymorphisms and the susceptibility to Graves' disease

VernacularTitle:CTLA-4基因与Graves病易感性的关联研究
Author: Ruyi QU ; Shengxian LI ; Jie ZHENG ; Wei LIU ; Binli LIU ; Zhiyi SONG
Publication Type:Journal Article
Keywords: Graves' disease; Polymorphism,single nucleotide; Cytotoxic T lymphocyte antigen 4
From: Chinese Journal of Endocrinology and Metabolism 2014;30(1):35-37
CountryChina
Language:Chinese
Abstract: Objective To determine whether the single nucleotide polymorphisms (SNPs) rs231775 and rs3087243 of the cytotoxic T lymphocyte antigen 4 (CTLA-4) gene are associated with susceptibility to Graves' disease (GD) in Chinese Han population.Methods Patients were enrolled from outpatient department and wards.Blood samples from each subject were collected to extract DNA,and the genotypes were determined by TagMan-MGB probe.Results The frequencies of allele G (OR =1.244,95％ CI 1.124-1.377,P＜0.01) and genotype GG (55.3 ％ vs 49.1％,OR =1.279,95 ％ CI 1.126-1.454,P＜0.01) of rs231775 in GD group were higher than those in control group.The frequencies of allele G (OR =1.303,95％ CI 1.166-1.457,P＜0.01) and genotype GG (76.8％ vs 71.8％,OR=1.302,95％ CI 1.143-1.484,P＜0.01) of rs3087243 in GD group were also higher.Conclusion GG genotypes in rs231775 and rs3087243 of CTLA-4 gene are related to the high risk of GD.