Effect of finasteride on reducing hemorrhage in holmium lasterenucleation of prostate
10.3760/cma.j.issn.0254-9026.2014.03.012
- VernacularTitle:术前服用非那雄胺对减少钬激光前列腺剜除术中出血作用
- Author:
Meng GU
;
Qi CHEN
;
Yanbo CHEN
;
Zhong WANG
;
Zhikang CAI
- Publication Type:Journal Article
- Keywords:
Prostatic hyperplasia;
Hemorrhage;
Transurethral resection of prostate
- From:
Chinese Journal of Geriatrics
2014;33(3):264-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of preoperative oral finasteride on patients with benign prostate hyperplasia (BPH) undergoing holmium lasterenucleation of prostate (HoLEP).Methods A total of 156 BPH patients from Department of Urology in Shanghai Ninth People's Hospital from Sep.2010 to Mar.2012 was analyzed retrospectively.79 patients receiving oral 5 mg/d finasteride before operation were selected as medication group,and the 77 patients without taking finasteride were selected as control group.The perioperative data,including operation time,amount of washing fluid during operation,preoperative and postoperative changes of hemoglobin level and postoperative bladder washing time were compared between two groups.Results Compared with control group,the changes of hemoglobin level after HoLEP,amount of washing fluid during operation,and postoperative bladder washing time with normal saline were significantly decreased in experimental group[(1.08±0.27) g/L vs.(1.55±0.32) g/L,(27.51±3.67) L vs.(36.89±6.47) L,(24.85±4.17) h vs.(35.87±5.10) h,all P＜0.05].Conclusions Oral finasteride before HoLEP can reduce perioperative bleeding and the volume of bladder irrigation with normal saline.
