Efficacy analysis of intravenous thrombolysis after cardiopulmonary resuscitation for patients with acute myocardial infarction and cardiac arrest
10.3760/cma.j.issn.0254-9026.2014.03.003
- VernacularTitle:急性心肌梗死心脏骤停患者心肺复苏后静脉溶栓疗效分析
- Author:
Xiaoli ZHANG
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Cardiac arrest;
Cardiopulmonary resuscitation;
Intravenous thrombolysis
- From:
Chinese Journal of Geriatrics
2014;33(3):232-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of intravenous thrombolysis in the treatment of patients with acute myocardial infarction (AMI) and cardiac arrest after cardiopulmonary resuscitation.Methods 120 patients with AMI and cardiac arrest admitted in our hospital from Mar 2009 to Mar 2013 were divided into thrombolytic group (n=50) and control group (n=70) according to the voluntary principle.The recanalization rate,return time of spontaneous circulation,left ventricular ejection fraction (LVEF) and creatine kinase-MB (CK-MB),complications and hospital mortality rate were compared between two groups.Results The recanalization rate was significantly higher in thrombolytic group than in control group (76％ vs.11.4％,x2 =84.81,P＜ 0.05).Restoration of spontaneous circulation was significantly shorter and LVEF after one week of treatment and CK-MB peak were significantly higher in thrombolytic group than in the control group (t=6.796,4.342,2.923,respectively,P＜0.001 or 0.05).The incidences of heart failure,angina,arrhythmia,and re-infarction were significantly lower in thrombolytic group than in control group (x2 =6.10,20.95,8.52,11.10,respectively,all P＜0.05).There were no significant differences in the incidences of intracranial hemorrhage and upper gastrointestinal bleeding between thrombolytic group and control group (x2 =2.19,3.74,both P＞0.05).Hospital mortality rate was significantly lower in thrombolytic group than in control group (10 ％ vs.25.7 ％,x2 =4.65,P＜0.05).Conclusions Intravenous thrombolysis has a higher recanalization rate,faster recovery time of spontaneous circulation,fewer complications and higher hospital survival rate for the treatment of cardiac arrest in patients with acute myocardial infarction after cardiopulmonary resuscitation.
