Passive Skeletal Muscle Excursion after Tendon Rupture Correlates with Increased Collagen Content in Muscle.
10.3349/ymj.2014.55.5.1395
- Author:
Il Hyun KOH
1
;
Ho Jung KANG
;
Sang Woo JEON
;
Jae Han PARK
;
Yun Rak CHOI
Author Information
1. Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, Korea. yrchoi@yuhs.ac
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Tenotomy;
muscle excursion;
collagen content
- MeSH:
Animals;
Collagen/*metabolism;
Hydroxyproline/metabolism;
Muscle, Skeletal/*metabolism;
Rabbits;
Tendon Injuries/*metabolism;
Tendons;
Tenotomy;
Time Factors
- From:Yonsei Medical Journal
2014;55(5):1395-1399
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study was designed to measure time-dependent changes in muscle excursion and collagen content after tenotomy, and to analyze the correlation between muscle excursion and collagen content in a rabbit model. MATERIALS AND METHODS: Twenty-four rabbits underwent tenotomy of the second extensor digitorum longus (EDL) muscles on the right legs and were randomly assigned to three groups based on the period of time after tenotomy (2, 4, and 6 weeks). The second EDL muscles on left legs were used as controls. At each time after tenotomy, passive muscle excursion and collagen content, determined by hydroxyproline content, were measured bilaterally, and the ratio of each value to the normal one was used. RESULTS: The mean ratio of muscle excursion after tenotomy to the value of the control decreased in a time-dependent fashion: 92.5% at 2 weeks, 78.6% at 4 weeks, and 55.1% at 6 weeks. The mean ratio of hydroxyproline content in muscle to the value of the control increased in a time-dependent fashion: 119.5% at 2 weeks, 157.3% at 4 weeks, and 166.6% at 6 weeks. There was a significant negative correlation between the ratio of hydroxyproline content in muscle after tenotomy to the control values and the ratio of muscle excursion after tenotomy to the control values (r=-0.602, p=0.002). CONCLUSION: The decrease in muscle excursion seems to correlate with the increase in collagen content in the muscle in a time-dependent fashion following tenotomy.
