Clinical significance of changes in peripheral lymphocyte count after surgery in early cervical cancer
10.3760/cma.j.issn.0529-567x.2014.03.012
- VernacularTitle:早期子宫颈癌患者手术后外周血淋巴细胞计数变化的临床意义
- Author:
Xin CHEN
;
Guonan ZHANG
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Gynecologic surgical procedures;
Lymphocyte count;
Prognosis
- From:
Chinese Journal of Obstetrics and Gynecology
2014;49(3):208-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical significance of changes in peripheral lymphocyte count after surgery in early cervical cancer.Methods The 123 patients with stage Ⅰ bl and Ⅱ al treated by abdominal type Ⅲ radical hysterectomy from May 2008 to December 2012 were reviewed.The median age of patients was 43 years old (range:30 to 66 years).The median follow-up was 25 months with a range of 5-61 months.Peripheral blood samples were obtained on pre-operative,post-operation day 3 and 7.The log-rank test was used to compare the homogeneity of progression-free survival functions across strata defined by categories of prognostic variables.The Cox proportional hazard model was used to assess the significance of potential prognostic factors for progression-free survival.Results Univariate analyses preoperative lymphocyte count (P =0.012) and lymph nodes metastases status (P =0.001) and parametrial invasion (P =0.013) were significant risk factors for progression-free survival rate.On multivariate analyses,preoperative lymphocyte count [hazard ratio (HR) =6.087,95％ CI:1.743-21.251,P =0.005] and lymph nodes metastases status (HR =5.984,95％ CI:1.803-19.802,P =0.003) were independent risk factor of progression-free survival rate.Conclusion Peripheral lymphocyte counts after cervical cancer surgery may be a important prognostic factor.
