Ultrasound-guided chemical ablation using compound lauromacrogol in treatment of tumor xenograft
10.3760/cma.j.issn.1004-4477.2014.01.020
- VernacularTitle:超声介导复方聚桂醇化学消融肿瘤的实验研究
- Author:
Zhenpeng QU
;
Zhikui CHEN
;
Yimi HE
;
Ensheng XUE
;
Liwu LIN
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
interventional;
Neoplasms,experimental;
Lauromacrogol;
Ethanol
- From:
Chinese Journal of Ultrasonography
2014;23(1):62-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the tumor chemical ablation and analgesic effects of compound lauromacrogol,and to explore a new method for ultrasound-guided tumor ablation.Methods 18 VX2 tumorbearing rabbits were randomly divided into saline group,ethanol group and compound lauromacrogol group,and the medicine was intratumoral injected guided by ultrasonography.After 4 times treatment,tumor contrast-enhanced ultrasonography,tumor growth inhibition rate and tumor tissue pathology were performed to evaluate the antitumor effects.The analgesic effect was evaluated using the pain model induced by formaldehyde test.Results Ultrasound-guided intratumoral injection of compound lauromacrogol showed significant antitumor effects with a tumor growth inhibition rate of 63.3 ％,which was higher than that of ethanol group.No apparent enhancement was found under contrast-enhanced ultrasonography,and pathology results confirmed wide necrosis.In saline,ethanol and compound lauromacrogol groups,the average accumulated points were 62.25 ± 9.79,21.00 ± 9.13 and 9.87 ± 3.10,respectively by formaldehyde test.Conclusions Ultrasound-guided chemical ablation using compound lauromacrogol showed complete antitumor and strong analgesic effects,which would be a new method for tumor ablation.
