Prediction of treatment response for cardiac resynchronization therapy by left ventricular twist using three-dimensional speckle tracking imaging in a heart failure canine model
10.3760/cma.j.issn.1004-4477.2014.01.019
- VernacularTitle:基于三维斑点追踪的左心室扭转功能预测心脏再同步化治疗疗效的实验研究
- Author:
Yongshi WANG
;
Xue GONG
;
Yangang SU
;
Jie CUI
;
Xianhong SHU
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Heart failure;
Ventricular function,left;
Cardiac resynchronization therapy;
Three-dimensional speckle tracking imaging
- From:Chinese Journal of Ultrasonography
2014;23(1):57-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess left ventricular (LV) twist in a rapid pacing induced heart failure canine model undergoing cardiac resynchronization therapy (CRT) by three-dimensional speckle tracking imaging (3D-STI).Methods Rapid right ventricular pacing (RVP) was utilized in 22 adult beagle dogs for 3 weeks to induce heart failure.Then 15 dogs received CRT for 2 weeks and others were treated as control.Apical full-volume acquisition of the LV was obtained in conscious animals at baseline,the end of 3-week RVP and the end of 2-week CRT.Peak LV apical (AP-Prot) and basal rotation (MV-Prot) along with peak twist (Ptw) and torsion (Ptor) were automatically calculated by TomTec 4D LV Analysis 3.0 software to identify the ideal parameter in predicting treatment response of CRT.Results After 2 weeks of CRT,LV ejection fraction(LVEF) increased and LV end-systolic volume(LVESV) decreased significantly in dogs with heart failure.CRT treatment response,defined as improvement of LVESV≥15％,was observed in 9 dogs.Significant difference was found in Ptw [(7.43 ± 0.61) vs (6.06 ± 0.89)°,P ＜0.05] and Ptor [(1.43 ± 0.45) vs (0.67 ± 0.36)°/cm,P ＜0.05] between responders and nonresponders.Ptw and Ptor predicted CRT response with satisfying sensitivity as 89％ and 85％,specificity as 83％ and 84％,respectively.Conclusions Peak twist and torsion evaluated by 3D-STI represented overall LV twist and demonstrated potential prediction value for treatment response of CRT.
