Association study of the gene MeCP2 polymorphisms with schizophrenia in female
10.3760/cma.j.issn.1674-6554.2014.01.009
- VernacularTitle:甲基化CpG结合蛋白-2基因多态性与女性精神分裂症患者的关联性研究
- Author:
Hongying HAN
;
Zhiyong ZHONG
;
Zhaoyu GAN
;
Houliang WANG
;
Jinbei ZHANG
;
Xiaogang CHEN
- Publication Type:Journal Article
- Keywords:
MeCP2 gene;
Polymorphism;
Female;
Schizophrenia;
Association study
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;23(1):29-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of methyl-CpG-binding protein2 (MeCP2) polymorphisms with female schizophrenia in Chinese Han population.Methods By using the technology based on microarray Chip,gene polymorphism analysis of 4 locus located in the gene MeCP2 was performed in 126 schizophrenia patients fulfilled with DSM-Ⅳ-TR criteria for schizophrenia and in 144 healthy controls.Chi square test was used to compare the inter-group differences of genotypic and allelic distribution.Haplotype case-control association analysis based on linkage disequilibrium was conducted using SNP stats online software after the data was screened.The significance of results was corrected by permutation test.Results To the point of Locus rs1616369 which located in Gene MeCP2,the distribution of the genotype G/A between two groups(24.8％ vs 34.3％) reached significance (P＜0.05) ; rs3027933,genotype G/C(25.6％ vs 34.8％),P＜0.05 ; rs17435,genotype T/A(25.6％ vs 35.5％),P ＜ 0.05 ; rs2239464,genotype C/A (58.5％ vs 71.8％),P＜ 0.05.The distribution prevalence of Haplotype GCCA was 0.1581 in case group,and 0.2389 in control group,reached significant difference(P＜0.05).Conclusion As to female MeCP2 gene,the genotype on the four locations might associate with the onset of schizophrenia,MeCP2 might be susceptibility gene of female schizophrenia.The Haplotype GCCA maybe the protective factor.
