The effect of lidocaine on plasma S100β protein in patients with supratentorial tumor surgery
10.3760/cma.j.issn.1673-4904.2014.09.014
- VernacularTitle:利多卡因对幕上肿瘤切除术患者血浆S100β蛋白的影响
- Author:
Yuming PENG
;
Wei ZHANG
;
Xiaoli ZHOU
;
Ruquan HAN
- Publication Type:Journal Article
- Keywords:
Anesthesia;
Supratentorial neoplasms;
Lidocaine;
S100 proteins
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(9):39-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of lidocaine on plasma S100β protein in patients with supratentorial tumor surgery.Methods Thirty patients with supratentorial tumor surgery were selected,ASA grade Ⅰ-Ⅱ grade.The patients were divided into lidocaine group and control group by random digits table with 15 cases each.In lidocaine group,a dose of 2％ lidocaine was administered as an intravenous bolus (1.5 mg/kg) after induction,followed by an intravenous infusion at rate of 2 mg/ (kg ·h) until the end of surgery.In control group,0.9％ sodium chloride was given in the same volume and the same rate.Bloods were sampled from bulb of jugular vein to measure the plasma S100β protein before surgery,end of surgery and 1 day after surgery.Results The plasma S100 β protein before surgery,end of surgery and 1 day after surgery in lidocaine group were (21.03 ± 11.67),(32.63 ± 10.14) and (34.16 ± 17.59) ng/L,in control group were (23.04 ± 13.32),(44.98 ± 16.63) and (39.85 ± 21.99) ng/L.There were no statistical differences in the plasma S100 β protein before surgery and 1 day after surgery between the 2 groups (P ＞ 0.05),but there was statistical difference end of surgery between the 2 groups (P ＜ 0.05).Conclusion Intraoperative infusion of lidocaine can decrease the plasma S100β protein end of supratentorial tumor surgery.
