Effects of hepatic stellate cells in hepatic diseases
10.3760/cma.j.issn.1673-9752.2014.01.021
- VernacularTitle:肝星状细胞在肝脏疾病中的作用
- Author:
Lei ZHANG
;
Yumin LI
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Hepatic fibrosis;
Hepatic satellite cells
- From:
Chinese Journal of Digestive Surgery
2014;13(1):73-76
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic satellite cell (HSC) is a kind of nonparenchymal cells in the liver,which releases various collagenous fibers and cytoskeletal proteins,playing an important role in the pathophysiological changes of the liver.In normal,HSCs maintain normal tissue architecture via regulating the synthesis and degradation of extracellular matrix (ECM) proteins.During liver injury,HSCs were activated.Activated HSCs are the main cells that lead to the accumulation of extracellular matrix,which is the main reason of hepatic fibrosis,cirrhosis and liver failure.Therefore,lucubrating the role and mechanism of HSC in the progress of hepatic disease and investiating the HSC-related therapeutic strategies have practical significances for the prevention and treatment of liver injury and raise of patients' survival rates in clinical practice.
