Advances in microRNA regulated hepatitis B virus X protein in the pathogenesis of hepatocellular carcinoma with hepatitis B virus infection
10.3760/cma.j.issn.1009-9158.2013.09.003
- VernacularTitle:HBV X蛋白调控微小RNA致肝细胞癌发生机制的进展
- Author:
Li LIN
;
Lei ZHENG
;
Qian WANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Trans-activators;
MicroRNAs;
Cell proliferation;
Apoptosis
- From:
Chinese Journal of Laboratory Medicine
2013;36(9):785-788
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are evolutionarily conserved small noncoding RNAs of-22 nucleotides that exist in a wide variety of organisms,including animals,plants and virus.Mature miRNAs are able to control gene expression at a post-transcriptional level,either by blocking mRNA translation or inducing their degradation.Hepatitis B virus X protein (HBX) is a 17000 protein that is implicated to play a crucial role in hepatocarcinogenesis.Recently,many studies have shown that HBX is associated with miRNA regulation,and is involved in regulating fundamental biological processes of tumor in cell proliferation,differentiation and apoptosis.
