The association between KCNJ5 gene polymorphism and primary hyperaldosteronism
10.3760/cma.j.issn.1000-6699.2013.10.011
- VernacularTitle:KCNJ5基因多态性与原发性醛固酮增多症的关联性研究
- Author:
Chao SHI
;
Nanfang LI
;
Hongjian LI
;
Feiya ZU
;
Delian ZHANG
;
Guijuan CHANG
- Publication Type:Journal Article
- Keywords:
Primary hyperaldosteronism;
KCNJ5;
GIRK4;
rs11221497
- From:
Chinese Journal of Endocrinology and Metabolism
2013;29(10):867-870
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between KCNJ5 gene polymorphism and primary hyperaldosteronism(PA).Methods A total of 248 PA patients and 816 essential hypertension (EH) patients were enrolled in this study,TaqMan assay was used to detect the rs1221497 polymorphism of KCNJ5 gene.Results The genotypes of rs1221497 were in Hardy-Weinberg equilibrium in both PA group and EH group,the genotype frequencies ofGG,GC,CC were 208,39,1 in PA group and 631,177,8 in EH group respectively,the allele frequencies in the two groups were 455,41 and 1 439,193 respectively.The frequencies of GG genotype and G allele in PA group were significantly higher than those in EH group.Logistic regression showed that GG genotype was closely associated with PA after adjusting age.Conclusions GG genotype and G allele may contribute to the occurrence of PA.
