Relationship between SOCS-3 gene polymorphism and abnormal glucose metabolism in the Xinjiang Uygur population

Li Cai; Juhong Zhang; Ling Zhou; Xiaoguang Yao; Na Lin; Jing Hong; Nanfang LI

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Relationship between SOCS-3 gene polymorphism and abnormal glucose metabolism in the Xinjiang Uygur population

VernacularTitle:SOCS-3基因多态性与新疆维吾尔族人群糖代谢异常的相关性研究
Author: Li CAI ; Juhong ZHANG ; Ling ZHOU ; Xiaoguang YAO ; Na LIN ; Jing HONG ; Nanfang LI
Publication Type:Journal Article
Keywords: Suppressor of cytokine signaling-3 gene; Abnormal glucose metabolism; Single nucleotide polymorphism; Uygur
From: Chinese Journal of Endocrinology and Metabolism 2013;29(10):853-857
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between SOCS-3 gene polymorphism and abnormal glucose metabolism in Xinjiang Uygur population.Methods According to different plasma glucose levels,1232individuals in Xinjiang Hetian area were divided into 3 groups,451 patients with pre-diabetes,252 patients with type 2 diabetes mellitus,and 529 healthy people as normal controls.Based on HapMap,the polymorphisms rs12953258,rs4969168,rs9914220 were selected as haplotypes,tagging SNP (htSNP) sufficiently covering the genetic variation of the whole gene.Associations of rs12953258,rs4969168,and rs9914220 within SOCS-3 with abnormal glucose metabolism in three groups of Xinjiang Uygur population were examined ; The genotype and allele frequencies and relative clinic data were compared among groups.Results The type 2 diabetes mellitus study with 451 individuals showed that the homozygosity for the C allele of rs12953258 polymorphism of SOCS-3 was associated with increased diabetes risk(OR=1.756,95％ CI 1.168-2.640).In addition,association between rs4969168 or rs9914220 and abnormal glucose metabolism in the Xinjiang Uygur population was not found.Age,total cholesterol,and body mass index were risk factors of diabetes mellitus,total cholesterol and low high density lipoprotein-cholesterol were risk factors of pre-diabetes in Uygur people.Conclusions The C allele of rs12953258 polymorphism of SOCS-3 gene may be an independent risk factor for abnormal glucose metabolism in Xinjiang Uygur population.