Association of rs2282679 A/C polymorphism in vitamin D binding protein gene with vitamin D deficiency
10.3760/cma.j.issn.1000-6699.2013.10.006
- VernacularTitle:维生素D结合蛋白基因rs2282679 A/C多态性与维生素D缺乏的关系
- Author:
Lei ZHANG
;
Lihua LI
;
Shaoyi PAN
;
Xueyan YIN
- Publication Type:Journal Article
- Keywords:
Vitamin D binding protein;
Genetic polymorphism;
25-hydroxyvitamin D;
Vitamin D deficiency
- From:
Chinese Journal of Endocrinology and Metabolism
2013;29(10):846-848
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] To investigate the association of rs2282679 A/C polymorphism in vitamin D binding protein gene with vitamin D deficiency in 1 216 participants.A standardized questionnaire was applied to collect information on alcohol consumption,smoking habits,and use of medications.Serum 25-hydroxyvitamin D [25 (OH) D] was determined by radioimmunoassay.Vitamin D binding protein genotypes were determined by SNaPshot method.1216participants included 457 women(37.6％),478 (39.3％)with vitamin D deficiency [25 (OH) D＜50 nmol/L],and 386 (31.7％) overweight/obese participants.The frequencies of rs2282679 CC,AC,and AA genotypes were 8.7％,41.0％,and 50.3％,respectively.The distributions of genotypes and alleles differed significantly between participants with sufficient vitamin D and those with vitamin D deficiency (P ＜ 0.05).There were significant differences in the serum levels of 25 (OH) D between three genotypes before and after being adjusted for covariates (P＜0.01).AA had a 22％ (OR =0.78,95％ CI 0.65-0.93,P =0.006) lowered risk of vitamin D deficiency compared with the whole studied population.Compared with CC genotype,AA had a 36％ lowered risk of vitamin D deficiency(OR =0.64,95 ％ CI 0.42-0.98,P =0.006),while there was no significant difference between AC and CC genotypes(OR=0.87,95％ CI0.57-1.34,P=0.53).In conclusion,the vitamin D binding protein rs2282679A/C polymorphism was significantly associated with serum level of 25 (OH) D and risk of vitamin D deficiency.
