Expressions and significance of ZNF217 in papillary thyroid carcinoma

VernacularTitle:锌指蛋白217在甲状腺乳头状癌组织中的表达及意义
Author: Liting ZHANG ; Wenyi WU ; Zhaoyang WANG ; Zhongxin HUANG ; Shize ZHU
Publication Type:Journal Article
Keywords: Zinc finger gene 217; Papillary thyroid carcinoma; Metastasis
From: Chinese Journal of Endocrinology and Metabolism 2013;29(9):779-781
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and clinical significance of zinc finger gene 217 (ZNF217) in human papillary thyroid carcinoma.Methods The expressions of ZNF217 mRNA and protein were detected by quantitative realtime PCR and Western blot in papillary thyroid carcinoma tissues (n =20) and adjacent normal tissues (n =20),and the data were analyzed.Results The expressions of ZNF217 mRNA and protein in papillary thyroid carcinoma were significantly higher than those in adjacent normal tissues (96.72 ± 44.19 vs 4.86 ±3.55,0.994 ± 0.172 vs 0.195 ± 0.061,both P＜0.01),being higher in the papillary thyroid carcinoma with capsule invasion compared with that without capsule invasion (P＜0.01).The expressions of ZNF217 mRNA and protein in papillary thyroid carcinoma were not related to gender,age,tumor size,TNM stage or lymph node metastasis (all P＞0.05).Conclusions The overexpression of ZNF217 may be associated with the oncogenesis and progress of papillary thyroid carcinoma and capsule invasion,and thus is expected to become a new target for prevention and treatment of papillary thyroid carcinoma.