Relationship of serum retinol binding protein 4 and cystatin C with lower extremity arterial disease in type 2diabetes mellitus
10.3760/cma.j.issn.1000-6699.2013.09.008
- VernacularTitle:视黄醇结合蛋白4、胱抑素C与2型糖尿病下肢动脉病变的关系
- Author:
Shu LIU
;
Qiang LI
;
Kai LIU
;
Binsong LIU
;
Yubing HAN
;
Jinchao ZHANG
- Publication Type:Journal Article
- Keywords:
Retinol binding protein 4;
Cystatin C;
Diabetes mellitus,type 2;
Atherosclerotic disease
- From:
Chinese Journal of Endocrinology and Metabolism
2013;29(9):768-771
- CountryChina
- Language:Chinese
-
Abstract:
A total of 209 type 2 diabetic patients were divided into three groups:without,with mild to moderate,or severe diabetic lower extremity arterial disease based on the ankle brachial index value.60 healthy subjects were used as a control group.Retinol binding protein4 (RBP4),cystatin C,and biochemical parameters were determined in all subjects.The results showed that RBP4 and cystatin C levels were progressively raised with the increasing severity of lower extremity arterial disease in various groups,being significantly higher in patients with type 2 diabetes mellitus with mild to moderate and severe arterial disease compared with control group (P＜0.05 or P＜0.01).RBP4 and cystatin C levels in groups with lower extremity arterial disease were significantly higher than those in the group without arterial disease (P＜0.01).Pearson correlation analysis showed that RBP4 level was positively correlated with total cholesterol,triglyceride,low density lipoprotein-cholesterol,fasting serum insulin,body mass index,cystatin C etc while negatively correlated with high density lipoprotein-cholesterol (P＜0.05 or P＜0.01).Logistic regression analysis showed that serum RBP4 and cystatin C were significantly associated with lower extremity arterial disease in type 2 diabetes mellitus.
