Correlation between polymorphism of estrogen receptor gene and non-alcoholic fatty liver disease in postmenopausal women
10.3760/cma.j.issn.1000-6699.2013.09.014
- VernacularTitle:雌激素受体基因多态性与绝经后女性非酒精性脂肪性肝病的相关性研究
- Author:
Muxu ZHAI
;
Shukai SUN
;
Honghua FEI
;
Yiqun PENG
;
Eryuan LIAO
- Publication Type:Journal Article
- Keywords:
Estrogen receptors;
Polymorphism,single nucleotide;
Non-alcoholic fatty liver disease
- From:
Chinese Journal of Endocrinology and Metabolism
2013;29(9):788-791
- CountryChina
- Language:Chinese
-
Abstract:
Genotypes of estrogen receptor gene (ER) α and β in 110 patients with non-alcoholic fatty liver disease (NAFLD) and 100 control subjects were examined by polymerase chain reaction-based restriction fragment length polymorphism.The haplotype analysis was conducted by SHEsis on-line computing platform.The results showed that there were no differences in the genotype frequencies and allele frequencies of ERα at Xba Ⅰ and Pvu Ⅱ enzyme cutting sites between two groups (P ＞ 0.05).There existed significant differences in the genotype frequencies and allele frequencies of ERβ at Rsa Ⅰ and Alu Ⅰ enzyme cutting sites between these two groups (P ＜ 0.05 or P ＜0.01).The risk of NAFLD in postmenopausal women with R or a allele was 1.833 (95％ CI1.209-2.779,P＜0.05)or 1.782 (95％ CI 1.037-3.061,P＜0.05) fold of that with allele r or A.The frequency of r-A haplotype in ERβ was significantly lower in NAFLD group than that in control group (OR =0.529,95％ CI 0.348-0.805).Logistic regression analysis showed the relationship of fasting blood glucose,triglyceride,body mass index,diastolic pressure,Alu Ⅰ genotype with NAFLD (all P＜0.01).The risk of NAFLD in postmenopausal women with Aa/aa genotype was 1.345 (95％ CI 1.028-2.505,P＜0.05) folds of that with AA genotype.
