Association between methylenetetrahydrofolate reductase gene C677T polymorphism and diabetic kidney disease in Chinese population: a meta-analysis
10.3760/cma.j.issn.0254-9026.2013.11.034
- VernacularTitle:亚甲基四氢叶酸还原酶基因C677T多态性与中国人群糖尿病肾病相关性的Meta分析
- Author:
Liang SUN
;
Songlan WANG
;
Xiaohong SHI
;
Ze YANG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Methylenetetrahydrofolate reductase;
Genomic structural variation;
Meta-analysis
- From:
Chinese Journal of Geriatrics
2013;32(11):1255-1258
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism and diabetic kidney disease in Chinese population.Methods After searching the related literatures from PubMed,Medline,EMBASE databases and common Chinese journal literature databases,meta-analysis was performed to assess the association of MTHFR C677T polymorphism with diabetic kidney disease according to the principles of systematic review based on the recessive model and dominant model respectively.Fixed effect model (M-H) was used to pool odd ratio (OR) after heterogeneity test.The Begg and Egger analysis were conducted to evaluate the publication bias.Results 10 literatures including a total of 2018 cases were included in the metaanalysis.No significant heterogeneity was detected.Data were pooled by fixed effect model.The total OR was 2.41 (95％CI=1.85～3.13) and 2.33 (95％CI=1.82～2.98) in recessive and dominant models respectively.No obvious publication bias was observed by Begg and Egger analysis.Conclusions The T allele of C677T polymorphism in MTHFR gene is positively associated with diabetic kidney disease in Chinese population.
