Acute megakaryocytic leukemia transformed from idiopathic myelofibrosis after 26 years: a case report and review
10.3760/cma.j.issn.0254-9026.2013.10.017
- VernacularTitle:迁延26年原发性骨髓纤维化转化为急性巨核细胞白血病一例分析及文献复习
- Author:
Chunling WANG
;
Baoan CHEN
;
Yufeng LI
;
Liang YU
;
Banghe DING
;
Jiabin ZHU
;
Zhengmei HE
- Publication Type:Journal Article
- Keywords:
Primary myelofibrosis;
Leukemia,Megakaryoblastic,Acute
- From:
Chinese Journal of Geriatrics
2013;32(10):1087-1089
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical data and laboratory features of acute megakaryocytic leukemia transformed from idiopathic myelofibrosis after 26 years in one case and the prognostic factors of myelofibrosis.Methods A case of acute megakaryocytic leukemia (M7) transformed from idiopathic myelofibrosis after 26 years was reported,and the clinical data was analyzed.Bone marrow cytology,cytogenetic and mutation detection in JAK2V617F were detected before and after transformation.Standard chemotherapeutic protocols including idarubicin plus cytarabine (IDA),homoharringtonine and cytarabine (HA),mitoxantrone and cytarabine (MA),pirarubicin plus cytarabine (TA) sequential therapies were performed.Results JAK2V617F mutation and normal karyotype were found before and after the transformation.This patient was treated with standard chemotherapeutic protocols of IDA,HA,MA and TA sequential therapies until getting complete remission,and he lived well till now.Conclusions Chromosome karyotype is related to the prognosis of IMF.Acute megakaryocytic leukemia (M7) with the normal karyotype transformed from the IMF can achieve complete remission by rational consecutive chemotherapy.
