Analgesic effect of dexmedetomidine versus propofol on patients with coronary heart disease undergoing noncardiac surgery
10.3760/cma.j.issn.0254-9026.2013.11.008
- VernacularTitle:右美托咪定和异丙酚用于冠心病患者非心脏手术的镇痛效果比较
- Author:
Zhenyu YU
;
Guofeng LIU
;
Jianhong YU
- Publication Type:Journal Article
- Keywords:
Dexmedtomidine;
Propofol;
Coronary
- From:
Chinese Journal of Geriatrics
2013;32(11):1161-1163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the analgesic effect of dexmedetomidine and propofol on patients with coronary heart disease undergoing noncardiac surgery.Methods 86 patients in our hospital from Sep 2009 to Sep 2011 aged 55-76 years weighing 42-60 kg,who were scheduled for epidural anesthesia in routine,were randomly assigned to 2 groups:dexmedtomidine (Dex) group and propofol group (n=43,each).Visual analogue scale/score (VAS) analgesia score and ramsay sedation score were used to observe the analgesic effect after surgery.Serum concentration of cortisol,insulin and glucose were observed and compared between Dex and propofol group before and 4,24,48h after surgery.Patient satisfaction was surveyed.Results The analgesic effect evaluated by VAS and Ramsay scores was better in Dex group than in propofol group at different time after surgery (t=5.368,2.262,7.147,5.881,7.861,4.810,all P＜0.05).Serum concentrations of cortisol,insulin and glucose were lower in Dex group than in propofol group before and 4,24,48 h after surgery (t=3.076,2.042,4.090,all P＜0.05).The satisfaction rate was 93.0％ (40/43) in Dex group.Conclusions Dexmedetomidine has a better analgesic effect than propofol,and it is safe and feasible for patients with coronary heart disease undergoing noncardiac surgery.
