Chest computer tomography and serum tumor markers for lung cancer screening

VernacularTitle:胸部CT及血清肿瘤标志物检测对肺癌筛查的价值
Author: Yuan HE ; Weimin WANG ; Dan FENG ; Qiang ZENG
Publication Type:Journal Article
Keywords: Lung cancer; Detection rate; Chest computer tomography; Tumor markers; Screening
From: Chinese Journal of Health Management 2013;7(5):325-328
CountryChina
Language:Chinese
Abstract: Objective To assess the value of chest computer tomography (CT) and serum tumor marker in lung cancer screening among health check-up populations.Methods A total of 88 596 adults who had a medical check-up (including chest CT,chest DR,and tumor biomarkers test) in our center were enrolled in this investigation.Clinical diagnosis of lung cancer was confirmed by three professional doctors.Receiver operating characteristic (ROC) curve was used to assess the relationship between serum level of tumor biomarkers and lung cancer.Results The average detection rate of lung cancer was 59.8/100 000 in our center during 2007 and 2011 (men 42.9/100 000,women 92.2/100 000).Rate of positive results of chest CT was 94.3％,which was approximately 2 times of chest DR.Moreover,carcinoembryonic antigen (CEA) testing was effective in early diagnosis of lung cancer with higher sensitivity (73.6％) and specificity (57.1％).Conclusion This study suggests that health checkup centers should pay more attention to lung cancer screening in high risk populations,and new technologies might be used to facilitate the early diagnosis of lung cancer.