Effects of metaformin on body weight management and blood glucose control in over-weight patients with newly diagnosed type 2 diabetes
10.3760/cma.j.issn.1674-0815.2013.05.002
- VernacularTitle:初发2型糖尿病肥胖患者体重管理的5年效果及对血糖的影响
- Author:
Hui LI
;
Mingxiao SUN
;
Lei JIANG
;
Yao WANG
- Publication Type:Journal Article
- Keywords:
Body mass index;
Diabetes mellitus,type 2;
Obesity;
Metformin
- From:
Chinese Journal of Health Management
2013;7(5):292-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of metformin on blood glucose control and body weight management in over-weight patients with newly diagnosed type 2 diabetes mellitus (T2DM).Methods A retrospective study was performed in T2DM patients who were treated with metaformin (male 38,female 23,mean age (50.8 ± 7.9) years old).Based on body mass index (BMI),all the participants were assigned to obese,over-weight and normal weight group.Analysis of variance and multivariate analysis were used to confirm the effects of metformin on blood glucose and body weight.Results Fasting blood glucose (FBG),HbA1 c and BMI were significantly reduced over 2 years.In comparison with baseline,BMI of the obesity and overweight group was significantly decreased during follow up (P ＜ 0.05),while BMI of the normal weight group increased by 0.7 kg/m2.At baseline,FBS and HbAlc of the obese group were lower than those of the normal weight group (FBS (7.3 ± 0.8) vs.(11.8 ± 4.8) mmol/L,P ＜ 0.05 ; HbA1 c (6.8 ± 1.2) ％ vs.(8.5 ±3.1)％,P ＜0.05),whereas insulin level was higher than that of the normal weight group ((2.20 ± 0.36) vs.(1.87 ± 0.29) U,P ＜ 0.05).At 2 years,HbA1 c was reduced on average by 2.5％,1.4％ and 1.9％ in the obesity,over-weight and normal weight group,respectively.Conclusions The present study demonstrates the beneficial effect of metformin on newly diagnosed diabetics,especially obese patients.
