The effectiveness and safety of 125I seed implantation for treatment of gastric cancer
10.3760/cma.j.issn.2095-2848.2013.04.003
- VernacularTitle:125I粒子植入治疗胃癌有效性与安全性评价
- Author:
Lei ZOU
;
Kaiyuan LUO
;
Zhenhuan MA
;
Bo LI
;
Xiaogang LI
;
Jianbiao XU
;
Jiong LU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Brachytherapy;
Iodine radioisotopes
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2013;33(4):248-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effectiveness of 125I seed implantation for gastric cancer and to determine whether the therapy could increase the survival rate.Methods Seventy-six gastric cancer patients in stage Ⅱ or Ⅲ were involved and randomly divided into treatment group (n =42) and control group (n =34)by simple random sampling method.The patients in the control group underwent D2 or D3 surgery and the patients in treatment group underwent D2 or D3 surgery plus interstitial implantation of 125I seeds.All patients signed the informed consents.Treatment results were evaluated as CR,PR,NC and PD.CR and PR were considered as effective and the effective rate was calculated.All patients were followed up and the three-or five-year survival rate was calculated,the complications were examined.x2 test was used to compare the significant difference between the two groups.Results The total effective rate in control group was 50.00％ (17/34),lower than that of treatment group (73.81％,31/42; x2 =4.578,P＜0.05).In the treatment group,the three-year and five-year survival rates were 61.90％(26/42) and 42.86％(18/42) respectively,and the corresponding rates in the control group were 11.76％(4/34) and 0(0/34) respectively (x2=19.771,19.094,both P＜0.001).Both of the two groups had few severe side effects.Conclusion Radical surgery plus 1~Iseed implantation is effective and safe for the treatment of stage Ⅱ or Ⅲ gastric cancer and can further improvelong-term survival.
