Role and clinical significance of ductular reaction in the development of hepatocarcinogenesis

VernacularTitle:胆管反应在肝癌发生发展中的作用及其临床意义
Author: Fei YE ; Yingying JING ; Lixin WEI
Publication Type:Journal Article
Keywords: Ductular reaction; Hepatic progenitor cell; Intermediate hepatobiliary cell; Microenvironment of hepatocellular carcinoma
From: Chinese Journal of Hepatobiliary Surgery 2013;19(9):716-719
CountryChina
Language:Chinese
Abstract: Ductular reaction (DR) is a phenomenon that refers to impaired hepatocellular proliferation and activated hepatic stem cells at times of demand such as hepatic regeneration.The components of ductular reactions are thought to be derived from activated hepatic progenitor cells,intermediate hepatobiliary cells,and reactive ductular cells.DRs are thought to play two roles in hepatocarcinogenesis:their hepatic progenitor cells may undergo malignant transformation and migration,and they may contribute to the development of the tumor's microenvironment.Exploring DR phenotype,cellular diversity,and relationship to hepatocarcinogenesis will further enhance our understanding of the pathogenesis of human hepatocellular carcinoma with an ultimate goal of developing new therapies.