Serum CA19-9, CA242 and CEA in the diagnosis and prognosis of combined hepatobiliary calculus and cholangiocarcinoma

VernacularTitle:肿瘤标志物在肝胆管结石合并胆管癌诊断与预后评估中的价值
Author: Changjun LIU ; Dezhen PENG ; Jinhiu YANG ; Bo JIANG ; Jinshu WU
Publication Type:Journal Article
Keywords: Cholelithiasis; Bile duct neoplasms; Antigens,neoplasm; Diagnosis; Prognosis
From: Chinese Journal of Hepatobiliary Surgery 2013;19(9):665-668
CountryChina
Language:Chinese
Abstract: Objective To study the values of serum CA19-9,CA242,CEA,alone or in combination in the diagnosis and prognosis of combined hepatobiliary calculus and cholangiocarcinoma (HCWC).Method Serum CA19-9,CA242,CEA in 100 patients with HCWC,70 patients with hepatobiliary calculus combined with cholangitis and 30 patients with hepatic hemangioma (normal bile duct group) were preoperatively studied.Results When the serum levels of CA19-9,CA242,CEA were separately used in the diagnosis of HCWC,the sensitivity of CA19 9 was highest,but its specificity was significantly lower than that of CA242 and CEA (P＜0.01).Patients with all the three tumor markers raised had significantly lower survival than those of patients with only one or two raised markers (P＜0.05).Conclusions The diagnostic rate for CA19 9 in HCWC was better than that of CEA and CA242.A joint detection improved the diagnostic specificity.Raised tumor markers were associated with progression of HCWC.Survival was worse in patients with 3 raised markers than those with 2 or 1 raised markers.