Experimental carotid-jugular shunting pulmonary hypertension in piglet monitored by ultrasound
10.3760/cma.j.issn.1004-4477.2013.09.020
- VernacularTitle:超声监测颈动-静脉分流实验猪慢性肺动脉高压形成
- Author:
Ji WU
;
Baoshi ZHENG
;
Shuaiwei LUO
;
Xiyu HUANG
;
Qun LI
;
Xiaoju LUO
;
Liping GUO
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Hypertension,pulmonary;
Carotid-jugular shunt;
Model,animal
- From:
Chinese Journal of Ultrasonography
2013;22(9):800-803
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the availability and usefulness of echocardiography in piglet of experimental carotid-jugular shunting pulmonary hypertension.Methods Fifty-one 1-month-old piglets were randomly divided into surgical shunt group(CA-JV,n =45) and sham group(n =6).In shunt group,left CA-JV shunt was esteblished by end-to-side vascular anastomosis from left carotid artery to jugular vein.Piglets in sham group received a sham operation.Periodic hemodynamic evaluation of the carotidjugular shunt and heart were performed by ultrasound examination post-surgery.Tricuspid regurgitation and pulmonary regurgitation were monitored for evaluating pulmonary systolic pressure and mean pressure.Results In CA-JV group,32 piglets survived to end point of experiment and 27 maintained a persistent shunting (success rate 60％).Tricuspid regurgitation and pulmonary regurgitation occurred increasingly and pulmonary pressure had risen gradually since 4 months post-surgery (P ＜ 0.05).Those were coincided with the results of right catheterization and pulmonary pathology.Conclusions Ultrasound can monitor experimental carotid-jugular shunting pulmonary hypertension that shows practical value for further study in the mechanism and treatment of pulmonary hypertension due to increased pulmonary blood flow.
