The platelet characteristics of 22q11 microdeletion and its clinical application
10.3760/cma.j.issn.1008-1372.2013.10.009
- VernacularTitle:22q11微缺失综合征的血小板特征及其临床应用初探
- Author:
Xicheng DENG
;
Qi AI
;
Zhiping TAN
;
Pingbo LIU
;
Erjia HUANG
- Publication Type:Journal Article
- Keywords:
Chromosome deletion;
Syndrome;
Chromosomes,human,pair 22;
Heart defects,congenital/genetics;
Blood platelets
- From:
Journal of Chinese Physician
2013;15(10):1327-1329
- CountryChina
- Language:Chinese
-
Abstract:
Objective 22q11 microdeletion is featured with hemotological dysfunction,among others:hypocalcemia,thrombocytopenia and megathrombocyte.This study was trying to work out the platelet characteristics of 22q1 1 microdeletion patients and its potential clinical application.Methods A total of 80 cases who had undergone open-heart surgery were selected and confirmed with fluorescence in situ hybridization (FISH) to have 22q1 1 microdeletion among 40 cases while the others were negative.The relevant data in full blood routine of all the 80 cases in hospital information system (HIS) then were collected and analyzed with suitable statistical methods.Results The mean platelet volume in microdeletion group was statistically higher than that in the control group [(11.20 ± 1.94)fL vs (8.95 ± 1.58) fL,P ＜0.01].The area under the receiver operating characteristic (ROC) curve was 0.82,meaning significant predictive values.The corresponding sensitivity and specificity for mean platelet volume (MPV) =10 fL were 70.0 ％ and 80.0 ％,respectively.Conclusions MPV in congenital heart defect patients with 22q11 is significantly higher than those without 22q11.It is an effective method for preliminary screening 22q11.Being obtained from full blood routine data,it is economic and quick.MPV =10 fL can be used as a cutoff for guidance for irradiated blood transfusion postoperatively.
