Observation of the effect of Sodium Starch Glycolate in the treatment of children with recurrent respiratory tract infection and its influence on cellular and humoral immunologic function
10.3760/cma.j.issn.1008-6706.2013.21.036
- VernacularTitle:羧甲淀粉钠对反复呼吸道感染患儿细胞及体液免疫功能的影响与疗效观察
- Author:
Qingguang CHEN
- Publication Type:Journal Article
- Keywords:
Respiratory tract infection;
Child;
Sodium Starch Glycolate;
Cell immunologic function;
Humoral immunological
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(21):3280-3282
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the curative effect of Sodium Starch Glycolate on children with recurrent respiratory tract infection(RRI) and its influence on cellular and humoral immunologic function.Methods 50 RRI children were selected as treatment group and treated by Sodium Starch Glycolate orally for 12 weeks.The changes of cellular and humoral immunologic function before and after treatment,and the curative effect and adverse reaction were observed.Another 3 0 non RRI but ARI children who received outpatient medical treatment during the same period were selected as control group.Results Before treatment,the level of CD4+ and CD4+/CD8+ of treatment group were significantly lower than that of control group,but the level of CD8+ was the opposite(t =2.27,2.25,2.91,P ＜0.05 or P ＜0.01).After treatment for 12 weeks,the level of CD4+ and CD4+/CD8+ of treatment group increased significantly compared with before treatment,but the level of CD8+ reduced significantly (t =2.12,2.17,2.43,all P ＜ 0.05).The plasma levels of IgG,IgA and IgM of treatment group were significantly lower than those of the control group before treatment (t =2.45,2.91,2.44,P ＜ 0.05 or P ＜ 0.01).After treatment for 12 weeks,the levels of IgG,IgA and IgM of treatment group increased significantly(t =2.14,2.25,2.31,all P ＜ 0.05),and the total effective rate was up to 96.0％ (48/50).No obvious adverse reaction occurred during treatment.Conclusion Sodium Starch Glycolate in treating RRI children shows good effect and high safety,which maybe relate with regulating the imbalance of the T cell subsets and immune globulin and enhancing the cellular and humoral immunologic function.
