The effect of letrozole plus metformin on infertility of polycystic ovary syndrome
10.3760/cma.j.issn.1008-6706.2013.21.035
- VernacularTitle:来曲唑联合二甲双胍改善多囊卵巢综合征不孕症的效果分析
- Author:
Jinghua WANG
;
Haiyan SUN
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Infertility,female;
Letrozole;
Metformin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(21):3278-3280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of letrozole plus metformin on infertility of polycystic ovary syndrome(PCOS).Methods According to the digital table,90 patients with infertility of PCOS were randomly divided into the control group(n =45 cases) and the treatment group(n =45 cases).The patients of the control group were treated though clomiphene,while the patients of the treatment group were treated though letrozole plus metformin.The ovulation rate,pregnancy rate,sex hormones and insulin resistance were detected.Results The homeostasis model assessment of insulin resistance index (HOMA-IR) was (5.72 ± 2.37) before treatment and (3.16 ± 1.39) after treatment in the treatment group.HOMA-IR was (5.69 ± 2.40) before treatment and (4.81 ± 2.06) after treatment in the control group.There was a significantly decrease in the treatment group (t =3.7246,P ＜ 0.05).The ovulation rate was 80％ in the treatment group,while 60％ in the control group,the difference between the two groups was significant(x2 =4.06,P ＜0.05).The pregnancy rate was 48.9％ in the treatment group,while 28.9％ in the control group,the difference between the two groups was significant (x2 =5.77,P ＜ 0.05).Conclusion Letrozole plus metformin could promote the ovulation and decrease insulin resistance.
